4 March – Ian Syster wins his first national title in the men's marathon, clocking 2:13:30 in Durban.
18 March – The Department of Health declines the offer of a large donation of HIV test kits made by Guardian Scientific Africa Incorporated
April
5 April – George Bizos is awarded the 2001 International Trial Lawyer Prize of the Year by the International Academy of Trial Lawyers
11 April – Pfizer Inc., a pharmaceutical company, agrees to supply AIDS patients attending public hospitals with an unlimited two-year supply of Fluconazole
30 April – South Africa and India sign a declaration of intent on co-operation in health and medicine
4 October – The first 40 (including 3 breeding herds) of a planned 1000 elephants is translocated from the over-populated Kruger National Park to the war-ravaged Limpopo National Park